Follow your doctor's instructions. Yohimbe dilates the blood vessels and can lower blood pressure. This Yohimbe (Pausinystalia johimbe) monograph is an excerpt from the 1999, first edition of Dr. Sharol's book "Herbal Medicine From The Heart of The Earth." Pausinystalia johimbe, (Rubiaceae), common name yohimbe, is a plant species native to western and central Africa (Nigeria, Cabinda, Cameroon, Congo-Brazzaville, Gabon, Equatorial Guinea). Call your doctor for medical advice about side effects. Monitor therapy.40, 41, 42, 43, 44, 45, Clinical trials report few serious adverse events.14, 16, 46 Case reports exist of rash, lupus-like syndrome, bronchospasm, arrhythmias, and death associated with yohimbine consumption.47, 48, 49, 50 Increased anxiety, irritability, and excitability have also been reported.10, 51, Animal studies suggest yohimbine may increase motor activity and seizures at higher dosages, may cause CNS stimulation and paralysis, and may precipitate psychoses in predisposed individuals. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. You may not be able to take yohimbine, or you may require a lower dose or special monitoring during therapy if you have any of the conditions listed above. How It Is Used. The active ingredient in the bark is an alkaloid called yohimbine and is thought to work by blocking the body’s alpha-2 adrenergic receptors, which are responsible for inhibiting or preventing erections. Home Delivery Common Content UI - Express Scripts ... alert icon The availability of clinical trial data renders findings from recent animal studies largely irrelevant. It is commonly sold as an herbal supplement to improve erectile function. Yohimbine is an indole alkaloid derived from the bark of the Central African yohimbe tree (Pausinystalia yohimbe) that is widely used as therapy for erectile dysfunction.Yohimbine use has been associated with occasional severe adverse events, but has not been linked to serum enzyme elevations or clinically apparent acute liver injury. Yohimbine may also be used for purposes other than those listed in this product guide. Use caution when driving, operating machinery, or performing other hazardous activities. Schum.) Yohimbine increases the amount of blood that is allowed to flow into the penis and prevents blood from flowing out of the penis. It can cause an erection. Usual Adult Dose for Erectile Dysfunction: 5.4 mg orally 3 times a day. Yohimbine is a monoamine oxidase inhibitor alkaloid. You receive free shipping in the USA. This information is not specific medical advice and does not replace information you receive from your health care provider. It is used to make medicines. If side effects occur, reduce to 2.7 mg orally 3 times a day and titrate gradually up to 5.4 mg orally 3 times a day. You may report side effects to FDA at 1-800-FDA-1088. Take yohimbine exactly as directed. Do not use during pregnancy or lactation. Qualitative and quantitative analyses of commercial products and yohimbe bark have been undertaken using high performance liquid chromatography, nonaqueous capillary electrophoresis, and gas chromatography-mass spectrometry.3, 5. Version: 4.01. Pausinystalia johimbe or commonly known as Yohimbe is native to western and central Africa. Yohimbe is used medicinally as stimulant, anti-diuretic, hypotensive, and bitter herb. The bark of the tree contains a chemical called yohimbine. Increased anxiety, irritability, and excitability have also been reported. The bark is gray to reddish-brown. You can purchase the 2020, third edition of this book with an expanded materia medica/monograph section, herbal formulas and directions on making herbal products in Dr. Sharol's Book Store. Authentic yohimbe bark may contain up to 6% total alkaloids, of which 10% to 15% is yohimbine. The bark of the West African yohimbe tree is rich in the alkaloid yohimbine, and the crude bark has been used traditionally as an aphrodisiac. Pausinystalia yohimbe is a West African tree thats bark contains yohimbine. There are other names (for this compound) are present too like Pausinystalia Yohimbe. Other minor indole alkaloids include corynantheidine, beta-yohimbine, pseudoyohimbine, rauwolscine, coryanthine, and allo-yohimbine.3 A comparison of chromatograms of authentic P. yohimbe bark extracts with those of commercial products containing yohimbine found that many products contained measurable quantities of the alkaloid yohimbine, but had very little of the other alkaloids previously reported in the species. Contraindicated in pregnancy. Its bark or bark extract is used in dietary supplement products marketed for sex drive, erectile dysfunction, weight loss, and bodybuilding. Common Names--yohimbe, yohimbe bark; Latin Names--Pausinystalia yohimbe; What Yohimbe Is Used For. Consult with a licensed healthcare professional before using any herbal/health supplement. The bark has been used traditionally as an aphrodisiac and to enhance sexual performance. If side effects occur, reduce to 2.7 mg orally 3 times a day and titrate gradually up to 5.4 mg orally 3 … You should talk with your health care provider for complete information about the risks and benefits of using this product. Of all the world’s sex-enhancing plants, yohimbe is among the very best known. Yohimbe bark has traditionally been used in Africa as an aphrodisiac (to increase sexual desire). Continue to take yohimbine and talk to your doctor if you experience. Yohimbe Bark Latin Name: Pausinystalia yohimbe Common Names: Yohimbe Bark Our Yohimbe Bark, which comes to us directly from our grower in Africa, comes in powdered as well as cut and sifted forms.This bark is certified kosher and wild crafted, meaning that it is both grown and harvested in the wild. Yohimbe may precipitate psychoses in predisposed individuals. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. Skip the missed dose if it is almost time for your next scheduled dose. The guideline statement noted that naturoceuticals are not recommended for the management of heart failure symptoms or for the secondary prevention of cardiovascular events, and that nutritional supplements are not recommended for the treatment of heart failure [Low-quality; Limited].52, The reproductive toxicology of yohimbine was investigated in rats. COMMON NAMES. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Yohimbine has been used primarily in the treatment of sexual dysfunction, weight (body fat) loss, and xerostomia (dry mouth). This drug should not be used in the presence of renal or hepatic dysfunction. Latin Names--Pausinystalia yohimbe. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This is not a complete list of side effects and others may occur. Yohimbine dilates blood vessels, thereby lowering blood pressure; however, its use as an antihypertensive agent has been abandoned.14 As a selective alpha-2-adrenergic antagonist, yohimbine has been used to test baroreflex-mediated bradycardia and the contribution of endogenous alpha-2-adrenergic blockade to baroreflex regulation in human studies.20, 21, 22, 23 The use of yohimbine in the management of syncope or orthostatic hypotension has, however, not been conclusively established. A drug form of yohimbine – yohimbine hydrochloride – has been studied for erectile dysfunction. Do not use extra yohimbine to make up the missed dose. The herb is currently used for sexual dysfunction, including erectile dysfunction in men. Although widely used to treat erectile dysfunction before the approval of newer drugs, current guidelines do not recommend its use. Yohimbine 6 mg given 3 times a day has been used in xerostomia trials. Limitations of the trials have been noted and include a lack of statistical power, reporting bias, and a strong placebo effect.14, 18, A more recent open-label study found yohimbine to be effective in managing anorgasmia (orgasmic dysfunction).19 Dosing was initiated at 20 mg, with 5 mg escalations to a maximum of 50 mg. A mean dose of 0.4 mg/kg body weight was determined.19 The development of tolerance was suggested by one reviewer.14. The bark of the tree contains a chemical called yohimbine. This product may be unsafe when used before surgery or other medical procedures. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Store this medication at room temperature away from moisture and heat. The Pausinystalia yohimbe plant is an evergreen which can grow to a height of almost one hundred feet. It has been investigated for use in treatment of sexual dysfunction.14, The American Urological Association (AUA) guidelines on the management of erectile dysfunction (2005) states that yohimbine is not recommended for the treatment of erectile dysfunction based on review of data and panel consensus.15, A number of meta-analyses published before the above-mentioned AUA guidelines were conducted on older clinical trials, all concluding that yohimbine was more effective than placebo in treating erectile dysfunction in most, but not all, men.14, 16, 17, 18 No serious adverse events were reported in the trials included in the meta-analyses. Copyright 1996-2021 Cerner Multum, Inc. Botanical names have been linked to an external site for further detail, the sites of choice being PROTA- Plant Resources of Tropical Africa (use Prota4U for search screen, or PROTA4U article list) & West African Plants - A Photo Guide (follow African Plant Database link below photos for description). The bark of the tree contains alkaloids, most notably yohimbine, which make up as much as 6% of the bark by weight. Latin Name: Pausinystalia yohimbe Common Names: Yohimbe Bark, Johimbe, aphrodine, corynine, quebrachine Our Yohimbe Bark, which comes to us directly from our grower in Africa, comes in powdered as well as cut and sifted forms.This bark is certified kosher and wildcrafted, meaning that it is both grown and harvested in the wild.

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