Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Lozenge: Avoid citrus fruits/juices and products containing citric acid within 30 minutes prior to or after use. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet. Protein enhances the absorption of zinc however a phytate rich diet (such as found in cereals, grains, corn and rice) can inhibit the absorption of zinc. 1987;21(1-2):223-228.doi: 10.1007/BF01974946. Zinc gluconate is more rapidly absorbed by the bloodstream, but the amount of zinc gluconate that has to be put into a supplement is relatively high.  |  Dietary sources of zinc are red meat, some seafood, and whole grains. At the end of four weeks hair, urine and erythrocyte zinc levels rose significantly (p less than 0.005, p less than 0.001, and p less than 0.001) during zinc picolinate administration. One study comparing the absorption of zinc picolinate, zinc citrate and zinc gluconate shows that there’s no significant change in any of these forms, but zinc picolinate did improve zinc absorption in humans. Prevention and treatment information (HHS). Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide. There was no significant change in any of these parameters from zinc gluconate, zinc citrate or placebo administration. Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral zinc salts. * Product details. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. The most important factor is to not consume your zinc supplement near a time when you also consume phytates, which are a compound found in grains. PLoS One. It contains zinc that’s been attached to a chelating agent.  |  biotin, multivitamin, ascorbic acid, calcium / vitamin d, Fish Oil. -, Am J Clin Nutr. HHS Zinc binding ligands and complexes in zinc metabolism. Zinc supplements … Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Zinc gluconate is the zinc salt of gluconic acid. The comparative oral absorption of zinc picolinate and zinc gluconate, an organic salt having similar bioavailability than zinc sulfate, was studied in healthy human volunteers. If oral iron supplements are required, separate the administration by 2 hours. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. A study published in the September 2006 issue of "Food Technology and Biotechnology" notes that zinc gluconate is more soluble than other zinc salts and easier on the stomach. 2014 Aug 6;9(8):e104621. Zinc, a trace element naturally found in foods such as nuts and beef, helps with numerous health functions, including immune system maintenance and wound healing. *[10] Maximum: 6 lozenges daily. Zinc is important for growth and for the development and health of body tissues. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Zinc binding in human milk: citrate versus picolinate. [Effect of different concentrations of various zinc complexes (picolinate, citrate, 8-hydroxyquinolate) in comparison with sulfate on zinc supply status in rats]. Zinc Absorption From Zinc Citrate, Zinc Gluconate and Zinc Oxide The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. 2014 Feb;144(2):132-6. doi: 10.3945/jn.113.181487. For best results, begin therapy 24 to 48 hours prior to symptom onset: Cold-Eeze Lozenge: Children ≥12 years and Adolescents: Oral topical: Dissolve one lozenge in mouth every 2 to 4 hours as needed. Dietary sources of zinc are red meat, some seafood, and whole grains. It’s often found in nasal zinc sprays and is sometimes called Orazinc. 1983 Aug;113(8):1653-6. doi: 10.1093/jn/113.8.1653. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This site needs JavaScript to work properly. Select one or more newsletters to continue. There is a very fine balance between zinc and copper during intestinal absorption. Expensive: Supplements that cost over $.15 per capsule are all-natural, vegan, and no-sugar options. The oral absorption, distribution, excretion, and bioavailability of zinc sulfate (ZnS), zinc gluconate (ZnG), and zinc‐enriched yeast (ZnY) in rats are fully and systemically compared for the first time. The individuals were randomly divided into four groups. Solgar Chelated Zinc. 1975 Feb;228(2):501-5 Consider therapy modification, Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. The oral absorption, distribution, excretion, and bioavailability of zinc sulfate (ZnS), zinc gluconate (ZnG), and zinc-enriched yeast (ZnY) in rats … Med Hypotheses. It's not a good idea to spray zinc gluconate, or any other form of zinc, up your nose. When dietary phytate is increased (as with some vegetarian diets), dietary absorption of zinc is decreased (IOM 2001). Follow your healthcare provider's instructions. Zinc gluconate is expected to work by increasing the effects of retinol palmitate and alisitol. Lozenge: Avoid citrus fruits/juices and products containing citric acid within 30 minutes prior to or after use. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Methods and results Risks of too much zinc Consider therapy modification, Quinolones: Zinc Salts may decrease the serum concentration of Quinolones. 1983 Jan;22(1):34-44. doi: 10.1007/BF02020783. The individuals were randomly divided into four groups. “A number of zinc supplements are commercially available, including zinc acetate, zinc gluconate, zinc picolinate, and zinc sulfate. Zinc gluconate is a popular form for the delivery of zinc as a dietary supplement providing 14.35% elemental Zinc by weight. Dietary supplement: Oral: One capsule/tablet daily or as directed by health care provider. NLM Sabatier M, Grathwohl D, Beaumont M, Groulx K, Guignard LF, Kastenmayer P, Dubascoux S, Richoz J, Habeych E, Zeder C, Moretti D, Zimmermann MB. When deciding which is the best form of zinc supplement for you, consider how easily it is absorbed and the correct dosage for your intended use. There is a very fine balance between zinc and copper during intestinal absorption. Zinc gluconate can cause a decrease in the absorption of Omadacycline resulting in a reduced serum concentration and potentially a decrease in efficacy. -, Proc Soc Exp Biol Med. Epub 2019 Jun 11. Separate dose administration of oral tetracycline derivative and oral zinc salts by at least 2 hours to minimize interaction. Hemilä H. Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Zinc gluconate is the zinc salt of gluconic acid. Zinc is an essential mineral that is found in almost every cell. The key to determining whether you should take zinc in the morning, night, or any other time of day is the absorption process of zinc. Zinc was measured in hair, urine, erythrocyte and serum before and after each period. This form is also easily absorbed by the body. Increase fluid intake during therapy. Research shows superior absorption with a zinc chelate in the form of zinc bisglycinate Zinc bisglycinate – a well-tolerated and well-absorbed zinc chelate – is comprised of one zinc molecule bound to two (bis = two) molecules of the amino acid glycine. People at risk of zinc deficiency or inadequacy need to include good sources of zinc in their daily diets. Dietary supplement: For use as a dietary supplement. Talk to your doctor if you have questions. Is Discontinued By Manufacturer : No; Zinc crosses the placenta and can be measured in the cord blood and placenta. Oxytetracycline: Zinc gluconate can cause a decrease in the absorption of Oxytetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy. Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Management: Give oral quinolones at several hours before (4 h for moxi- and sparfloxacin, 2 h for others) or after (8 h for moxi-, 6 h for cipro/dela-, 4 h for lome-, 3 h for gemi-, and 2 h for enox-, levo-, nor-, pe- or ofloxacin or nalidixic acid) oral zinc salts. Retinol palmitate promotes absorption of nutrients and fluids in the gut by restoring normal structure and function of intestinal cells. Zinc is a naturally occurring mineral. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Zinc gluconate is another form of chelated zinc. Zinc is a naturally occurring mineral. Zinc … You absorb between 15 and 35 percent of the zinc you consume. 1979 Mar 24;1(8117):677-8 Listing a study does not mean it has been evaluated by the U.S. Federal Government. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Consider therapy modification, Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Lozenge, Mouth/Throat [preservative free]: Cold-Eeze Sugar Free: 13.3 mg (18 ea) [gluten free, no artificial color(s), sugar free], Cold-Eeze Sugar Free: 13.3 mg (18 ea, 24 ea) [gluten free, no artificial color(s), sugar free; cherry flavor]. USA.gov. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2020 Jun;59(4):1371-1378. doi: 10.1007/s00394-019-01989-4. Zinc lozenges as cure for the common cold--a review and hypothesis. Take zinc gluconate with a full glass of water. Try this product which is a good choice if you … Lancet. Lozenge: Dissolve in mouth; do not chew. When dietary phytate is increased (as with some vegetarian diets), dietary absorption of zinc is decreased (IOM 2001). doi: 10.1002/14651858.CD010470.pub3. There was a small, insignificant rise in serum zinc during zinc picolinate, zinc citrate and placebo supplementation. Your healthcare provider may occasionally change your dose to make sure you get the best results from zinc gluconate. Epub 2009 Nov 10. We comply with the HONcode standard for trustworthy health information -, Detailed Zinc gluconate dosage information. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. High-dose calcium supplements may decrease zinc absorption, and taking zinc sulfate with black coffee has been shown to reduce the mineral’s absorption by half. Consider therapy modification, Tetracyclines: Zinc Salts may decrease the absorption of Tetracyclines. Consider therapy modification, Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. 1980 Dec;165(3):457-61 Pefloxacin The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Kumbargere Nagraj S, George RP, Shetty N, Levenson D, Ferraiolo DM, Shrestha A. Cochrane Database Syst Rev. Zinc gluconate is used to treat and to prevent zinc … Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Zinc, a trace element naturally found in foods such as nuts and beef, helps with numerous health functions, including immune system maintenance and wound healing. Medically reviewed by Drugs.com. If other oral polyvalent cations are needed, separate administration by 1 hour. [DSC] = Discontinued product, Zn-50: 50 mg [dye free, sugar free, yeast free], Cold-Eeze: 13.3 mg (18 ea [DSC]) [bubble-gum flavor], Cold-Eeze: 13.3 mg (20 ea [DSC]) [cinnamon flavor], Cold-Eeze: 13.3 mg (18 ea [DSC]) [cherry flavor], Cold-Eeze: 13.3 mg (18 ea [DSC]) [citrus flavor], Cold-Eeze: 13.3 mg (18 ea [DSC]) [honey-lemon flavor], Cold-Eeze: 13.3 mg (18 ea [DSC]) [menthol flavor], Cold-Eeze: 13.3 mg (18 ea [DSC]) [tropical fruit flavor], Cold-Eeze: 13.3 mg (2 ea, 10 ea, 18 ea, 24 ea) [gluten free; cherry flavor], Cold-Eeze: 13.3 mg (18 ea, 24 ea) [gluten free; honey-lemon flavor], Cold-Eeze: 13.3 mg (18 ea) [gluten free; tropical orange flavor]. Both Zinc gluconate and Zinc citrate are easily absorbable but Zinc gluconate is more soluble. The recommended dietary allowance of zinc gluconate increases with age. The results of this study suggest that zinc absorption in humans can be improved by complexing zinc with picolinic acid. Dose separation may not adequately minimize the significance of this interaction. The comparative absorption of zinc after oral administration of three different complexed forms was studied in 15 healthy human volunteers in a double-blind four-period crossover trial. Each group rotated for four week periods through a random sequence of oral supplementation including: zinc picolinate, zinc citrate, and zinc gluconate (equivalent to 50 mg elemental zinc per day) and placebo. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Each group rotated for four week periods through a random … Adverse reactions reported with excess dietary zinc (IOM 2001). Common cold: Note: For best results, begin therapy 24 to 48 hours prior to symptom onset: Oral: Dissolve one 13.3 mg lozenge in mouth every 2 to 4 hours as needed. Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans. Eur J Nutr. Zinc gluconate is used to treat and to prevent zinc … Consider therapy modification, Ceftibuten: Zinc Salts may decrease the serum concentration of Ceftibuten. 1984;6:139-67. doi: 10.1007/978-1-4613-2801-8_6. 1980 Oct;33(10):2145-50 JRSM Open. Frequency not defined; may vary with different salts. Consider therapy modification. Although the mechanism of action is not completely known, zinc supplementation may be used to increase … It takes just two milligrams of zinc carbonate to yield one milligram of elemental zinc. -, Am J Physiol. Many of these supplements contain several different forms of zinc to increase the absorption rate. Available for Android and iOS devices. Consider therapy modification, PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Avoid combination, Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Z Ernahrungswiss. Risks of too much zinc Age-dependent maximum daily dose: 12 to 17 years: 4 lozenges/day; ≥18 years: 6 lozenges/day. The exact amount depends on the amount of zinc you take in and whether you eat foods that increase or decrease zinc absorption. Wegmüller R, Tay F, Zeder C, Brnic M, Hurrell RF. Note: This is not a comprehensive list of all side effects.